Research workbench

Crystal structure of the A24U mutant xpt-pbux guanine riboswitch aptamer domain in complex with hypoxanthine

Analyse Crystal structure of the A24U mutant xpt-pbux guanine riboswitch aptamer domain… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4FEJ
Type: RNA
Length: 67 nucleotides
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: A24U mutant of the B. subtilis xpt-pbux guanine riboswitch aptamer domain
Ligands: NCO, HPA
Pockets: 2 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	A24U mutant of the B. subtilis xpt-pbux guanine riboswitch aptamer domain	rna	67	—	—

Ligands and binding sites

NCO · Cobalt hexammine(iii) · ligand · 7 copies · chains B
HPA · Hypoxanthine · ligand · chains B
ACT · Acetate ion · additive · 2 copies · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	872	0.72	0.78	40	ACT, NCO
2	198	0.41	0.73	18	empty

Compared structures

4FEJ · Crystal structure of the A24U mutant xpt-pbuX guanine riboswitch aptamer domain in… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4FEJ · PDBe 4FEJ

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.