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Structure of xylose-binding transcription activator xylr

Analyse Structure of xylose-binding transcription activator xylr in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4FE7
Type: protein
Length: 380 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Xylose operon regulatory protein
UniProt: P0ACI3
Ligands: XYS
Pockets: 4 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Xylose operon regulatory protein	protein	380	48% helix, 14% strand	P0ACI3

Ligands and binding sites

XYS · alpha-D-xylopyranose · sugar · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	377	0.67	0.80	45	XYS
2	343	0.58	0.76	39	empty
3	54	0.32	0.77	11	empty
4	71	0.31	0.74	18	empty

Compared structures

4FE7 · structure of xylose-binding transcription activator xylR · the same entry in another collection · chain A against A, TM-score 1.00
P0ACI3 · AlphaFold monomer V2.0 prediction for xylose operon regulatory protein (P0ACI3) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0ACI3
Elsewhere: RCSB PDB 4FE7 · PDBe 4FE7 · UniProt P0ACI3

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