Research workbench
Crystal structure of 14-3-3 protein from giardia intestinalis
Analyse Crystal structure of 14-3-3 protein from giardia intestinalis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4F7R
- Type
- protein
- Length
- 948 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 14-3-3 protein
- UniProt
- Q2QBT8
- Ligands
- SO4
- Pockets
- 11 · best druggability 0.55
Structure
x-ray diffraction · 4 distinct chains · 80% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 14-3-3 protein | protein | 236 | 81% helix, 0% strand | Q2QBT8 |
| B | 14-3-3 protein | protein | 237 | 80% helix, 0% strand | Q2QBT8 |
| C | 14-3-3 protein | protein | 237 | 79% helix, 0% strand | Q2QBT8 |
| D | 14-3-3 protein | protein | 238 | 82% helix, 0% strand | Q2QBT8 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 16 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 326 | 0.55 | 0.75 | 25 | empty |
| 2 | 304 | 0.54 | 0.75 | 24 | empty |
| 3 | 242 | 0.53 | 0.76 | 28 | SO4 |
| 4 | 229 | 0.52 | 0.76 | 27 | SO4 |
| 5 | 113 | 0.41 | 0.76 | 14 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1619 Ų buried · 5 hydrogen bonds · protein-protein
- C–D · 1363 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 1311 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 4F7R · Crystal structure of 14-3-3 protein from Giardia intestinalis · the same entry in another collection · chain D against D, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2QBT8
- Elsewhere: RCSB PDB 4F7R · PDBe 4F7R · UniProt Q2QBT8
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