Research workbench
Protelomerase tela mutant R255A complexed with caag hairpin DNA
Analyse Protelomerase tela mutant R255A complexed with caag hairpin DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4F43
- Type
- protein + DNA
- Length
- 352 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protelomerase; DNA hairpin
- UniProt
- Q7CWV1
- Pockets
- 4 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 56% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protelomerase | protein | 320 | 56% helix, 7% strand | Q7CWV1 |
| C | DNA hairpin | dna | 32 | — | — |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 455 | 0.74 | 0.83 | 40 | empty |
| 2 | 409 | 0.73 | 0.84 | 58 | empty |
| 3 | 56 | 0.28 | 0.74 | 15 | empty |
| 4 | 55 | 0.25 | 0.74 | 10 | empty |
Interfaces
1 interface between chains.
- A–C · 2492 Ų buried · 40 hydrogen bonds · protein-nucleic
Compared structures
- 4F43 · Protelomerase TelA mutant R255A complexed with CAAG hairpin DNA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7CWV1
- Elsewhere: RCSB PDB 4F43 · PDBe 4F43 · UniProt Q7CWV1
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