Research workbench
Crystal structure of the substrate binding domain of E.COLI dnak in complex with heliocin (residues 14 to 21)
Analyse Crystal structure of the substrate binding domain of E.COLI dnak in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4EZT
- Type
- protein
- Length
- 225 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chaperone protein dnak; Heliocin
- UniProt
- P0A6Y8, P83427
- Pockets
- 2 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chaperone protein dnak | protein | 217 | 42% helix, 26% strand | P0A6Y8 |
| B | Heliocin | protein | 8 | 0% helix, 25% strand | P83427 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 124 | 0.56 | 0.83 | 21 | empty |
| 2 | 128 | 0.44 | 0.77 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 784 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 4EZT · Crystal structure of the substrate binding domain of E.coli DnaK in complex with heliocin… · the same entry in another collection · chain A against A, TM-score 1.00
- P0A6Y8 · AlphaFold monomer V2.0 prediction for chaperone protein dnak (P0A6Y8) · a predicted model of the same protein · chain A against A, TM-score 0.48
- P83427 · AlphaFold monomer V2.0 prediction for heliocin (P83427) · a predicted model of the same protein · chain B against A, TM-score 0.46
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A6Y8
- Every structure of UniProt P83427
- Elsewhere: RCSB PDB 4EZT · PDBe 4EZT · UniProt P0A6Y8 · UniProt P83427
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