Research workbench
Crystal structure of Fab CR6261 (somatic heavy chain with germline- reverted light chain)
Analyse Crystal structure of Fab CR6261 (somatic heavy chain with germline- reverted… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4EVN
- Type
- protein
- Length
- 3,472 residues
- Chains
- 16
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fab heavy chain; Fab lambda light chain
- Pockets
- 20 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, G, I, K, M, O | Fab heavy chain | protein | 221 | 7% helix, 50% strand | — |
| B, D, F, H, J, L, N, P | Fab lambda light chain | protein | 213 | 8% helix, 50% strand | — |
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 825 | 0.70 | 0.76 | 78 | empty |
| 2 | 505 | 0.68 | 0.79 | 59 | empty |
| 3 | 478 | 0.67 | 0.79 | 58 | empty |
| 4 | 282 | 0.66 | 0.82 | 41 | empty |
| 5 | 596 | 0.65 | 0.76 | 68 | empty |
Interfaces
39 interfaces between chains.
- I–J · 1688 Ų buried · 14 hydrogen bonds · protein-protein
- M–N · 1686 Ų buried · 13 hydrogen bonds · protein-protein
- K–L · 1685 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 1680 Ų buried · 14 hydrogen bonds · protein-protein
- O–P · 1676 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 32 disulfide (disulfide).
Compared structures
- 4EVN · Crystal Structure of Fab CR6261 (somatic heavy chain with germline-reverted light chain) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4EVN · PDBe 4EVN
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