Research workbench
Recombinant human hexokinase type I complexed with glucose and phosphate
Analyse Recombinant human hexokinase type I complexed with glucose and phosphate in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1HKC
- Type
- protein
- Length
- 899 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- D-glucose 6-phosphotransferase
- EC
- 2.7.1.1
- UniProt
- P19367
- Ligands
- BGC, K, PO4
- Pockets
- 6 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | D-glucose 6-phosphotransferase (EC 2.7.1.1) | protein | 899 | 43% helix, 19% strand | P19367 |
Ligands and binding sites
- BGC · beta-D-glucopyranose · sugar · chains A
- K · Potassium ion · metal · 2 copies · chains A
- PO4 · Phosphate ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 590 | 0.64 | 0.75 | 72 | PO4 |
| 2 | 144 | 0.63 | 0.87 | 31 | BGC, PO4 |
| 3 | 487 | 0.59 | 0.74 | 56 | empty |
| 4 | 198 | 0.49 | 0.76 | 30 | empty |
| 5 | 78 | 0.36 | 0.76 | 18 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19367
- Elsewhere: RCSB PDB 1HKC · PDBe 1HKC · UniProt P19367
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