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Structure of ATU4243-GABA receptor

Analyse Structure of ATU4243-GABA receptor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4EQ7
Type: protein
Length: 640 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ABC transporter, substrate binding protein (polyamine)
UniProt: A9CGA5
Ligands: SO4
Pockets: 9 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	ABC transporter, substrate binding protein (polyamine)	protein	320	43% helix, 20% strand	A9CGA5

Ligands and binding sites

SO4 · Sulfate ion · ion · 9 copies · chains A, B
GOL · Glycerol · additive · 5 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	651	0.78	0.83	75	GOL
2	422	0.64	0.77	30	SO4, GOL
3	98	0.43	0.78	18	empty
4	145	0.42	0.75	29	SO4
5	64	0.41	0.81	20	empty

Interfaces

1 interface between chains.

A–B · 1675 Å² buried · 20 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 14 modified (engineered).

Compared structures

4EQ7 · Structure of Atu4243-GABA receptor · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A9CGA5
Elsewhere: RCSB PDB 4EQ7 · PDBe 4EQ7 · UniProt A9CGA5

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