Research workbench
Structure of yeast elongator subcomplex ELP456
Analyse Structure of yeast elongator subcomplex ELP456 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4EJS
- Type
- protein
- Length
- 715 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Elongator complex protein 4; Elongator complex protein 5; Elongator complex protein 6
- UniProt
- Q02884, P38874, Q04868
- Pockets
- 9 · best druggability 0.74
Structure
x-ray diffraction · 3 distinct chains · 32% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Elongator complex protein 4 | protein | 223 | 34% helix, 28% strand | Q02884 |
| B | Elongator complex protein 5 | protein | 221 | 29% helix, 27% strand | P38874 |
| C | Elongator complex protein 6 | protein | 271 | 33% helix, 22% strand | Q04868 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 437 | 0.74 | 0.84 | 52 | empty |
| 2 | 1072 | 0.73 | 0.77 | 93 | empty |
| 3 | 212 | 0.56 | 0.79 | 33 | empty |
| 4 | 108 | 0.48 | 0.80 | 23 | empty |
| 5 | 70 | 0.38 | 0.78 | 22 | empty |
Interfaces
2 interfaces between chains.
- B–C · 1491 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 1024 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 4EJS · Structure of yeast elongator subcomplex Elp456 · the same entry in another collection · chain A against A, TM-score 1.00
- P38874 · AlphaFold monomer V2.0 prediction for elongator complex protein 5 (P38874) · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q02884 · AlphaFold monomer V2.0 prediction for elongator complex protein 4 (Q02884) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q04868 · AlphaFold monomer V2.0 prediction for elongator complex protein 6 (Q04868) · a predicted model of the same protein · chain C against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02884
- Every structure of UniProt P38874
- Every structure of UniProt Q04868
- Elsewhere: RCSB PDB 4EJS · PDBe 4EJS · UniProt Q02884 · UniProt P38874 · UniProt Q04868
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