Research workbench
Structure of the TSG101 uev domain in complex with an ebola ptap late domain peptide
Analyse Structure of the TSG101 uev domain in complex with an ebola ptap late domain… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4EJE
- Type
- protein
- Length
- 303 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tumor susceptibility gene 101 protein; Matrix protein VP40
- UniProt
- Q99816, Q05128
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.75
Structure
x-ray diffraction · 3 distinct chains · 27% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tumor susceptibility gene 101 protein | protein | 143 | 27% helix, 32% strand | Q99816 |
| B | Tumor susceptibility gene 101 protein | protein | 142 | 28% helix, 30% strand | Q99816 |
| C, D | Matrix protein VP40 | protein | 9 | 0% helix, 11% strand | Q05128 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 137 | 0.75 | 0.93 | 25 | empty |
| 2 | 122 | 0.45 | 0.78 | 29 | empty |
Interfaces
3 interfaces between chains.
- A–B · 594 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 547 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 509 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 4EJE · Structure Of The Tsg101 UEV Domain In Complex With an Ebola PTAP late Domain Peptide · the same entry in another collection · chain A against A, TM-score 1.00
- Q99816 · AlphaFold monomer V2.0 prediction for tumor susceptibility gene 101 protein (Q99816) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99816
- Every structure of UniProt Q05128
- Elsewhere: RCSB PDB 4EJE · PDBe 4EJE · UniProt Q99816 · UniProt Q05128
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