Research workbench
Whole cytosolic region of ATP-dependent metalloprotease ftsh (G399L)
Analyse Whole cytosolic region of ATP-dependent metalloprotease ftsh (G399L) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4EIW
- Type
- protein
- Length
- 2,712 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent zinc metalloprotease ftsh
- EC
- 3.4.24.-
- UniProt
- Q5SI82
- Ligands
- ADP
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E | ATP-dependent zinc metalloprotease ftsh (EC 3.4.24.-) | protein | 458 | 51% helix, 7% strand | Q5SI82 |
| B, D, F | ATP-dependent zinc metalloprotease ftsh (EC 3.4.24.-) | protein | 446 | 52% helix, 9% strand | Q5SI82 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 6 copies · chains A, B, C, D, E, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 999 | 0.84 | 0.85 | 95 | empty |
| 2 | 989 | 0.84 | 0.85 | 87 | empty |
| 3 | 705 | 0.83 | 0.87 | 86 | empty |
| 4 | 1116 | 0.83 | 0.84 | 117 | empty |
| 5 | 341 | 0.82 | 0.91 | 59 | empty |
Interfaces
9 interfaces between chains.
- D–E · 2203 Ų buried · 33 hydrogen bonds · protein-protein
- B–C · 2146 Ų buried · 32 hydrogen bonds · protein-protein
- A–F · 2139 Ų buried · 36 hydrogen bonds · protein-protein
- A–B · 1590 Ų buried · 26 hydrogen bonds · protein-protein
- C–D · 1541 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 4EIW · Whole cytosolic region of atp-dependent metalloprotease FtsH (G399L) · the same entry in another collection · chain F against F, TM-score 1.00
- Q5SI82 · AlphaFold monomer V2.0 prediction for ATP-dependent zinc metalloprotease ftsh (Q5SI82) · a predicted model of the same protein · chain A against A, TM-score 0.61
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SI82
- Elsewhere: RCSB PDB 4EIW · PDBe 4EIW · UniProt Q5SI82
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