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RNA dependent RNA polymerase from dsrna bacteriophage PHI6

Analyse RNA dependent RNA polymerase from dsrna bacteriophage PHI6 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1HI8
Type: protein
Length: 1,328 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: P2 protein
UniProt: P11124
Ligands: MG
Pockets: 11 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	P2 protein	protein	664	44% helix, 14% strand	P11124

Ligands and binding sites

MG · Magnesium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

11 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	976	0.84	0.85	96	empty
2	387	0.77	0.87	39	empty
3	168	0.71	0.89	27	empty
4	175	0.69	0.88	27	empty
5	211	0.67	0.85	27	empty

Interfaces

1 interface between chains.

A–B · 50 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 50 modified (engineered).

Compared structures

1HI8 · RNA dependent RNA polymerase from dsRNA bacteriophage phi6 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11124
Elsewhere: RCSB PDB 1HI8 · PDBe 1HI8 · UniProt P11124

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