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Crystal structure of streptococcal beta-galactosidase

Analyse Crystal structure of streptococcal beta-galactosidase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4E8D
Type: protein
Length: 1,184 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glycosyl hydrolase, family 35
UniProt: Q97T90
Pockets: 11 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 26% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glycosyl hydrolase, family 35	protein	590	27% helix, 33% strand	Q97T90
B	Glycosyl hydrolase, family 35	protein	594	26% helix, 33% strand	Q97T90

Ligands and binding sites

GOL · Glycerol · additive · 13 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

11 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	704	0.73	0.79	71	empty
2	463	0.72	0.82	43	empty
3	437	0.66	0.78	37	empty
4	408	0.65	0.79	33	GOL
5	318	0.60	0.78	42	empty

Interfaces

1 interface between chains.

A–B · 1567 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

4E8D · Crystal structure of streptococcal beta-galactosidase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

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Every structure of UniProt Q97T90
Elsewhere: RCSB PDB 4E8D · PDBe 4E8D · UniProt Q97T90

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