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Crystal structure of hat domain of RNA14

Analyse Crystal structure of hat domain of RNA14 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4E85
Type: protein
Length: 1,107 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: MRNA 3'-end-processing protein RNA14
UniProt: Q6CII8
Pockets: 16 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 71% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	MRNA 3'-end-processing protein RNA14	protein	555	70% helix, 0% strand	Q6CII8
B	MRNA 3'-end-processing protein RNA14	protein	552	72% helix, 0% strand	Q6CII8

Pockets

16 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1149	0.82	0.83	104	empty
2	419	0.63	0.77	45	empty
3	321	0.57	0.76	40	empty
4	173	0.55	0.80	26	empty
5	266	0.55	0.76	28	empty

Interfaces

1 interface between chains.

A–B · 2706 Å² buried · 25 hydrogen bonds · protein-protein

Compared structures

4E85 · crystal STRUCTURE OF HAT DOMAIN OF RNA14 · the same entry in another collection · chain A against A, TM-score 1.00
Q6CII8 · AlphaFold monomer V2.0 prediction for mRNA 3'-end-processing protein RNA14 (Q6CII8) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6CII8
Elsewhere: RCSB PDB 4E85 · PDBe 4E85 · UniProt Q6CII8

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