Research workbench
Type II citrate synthase from vibrio vulnificus.
Analyse Type II citrate synthase from vibrio vulnificus. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4E6Y
- Type
- protein
- Length
- 426 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Citrate synthase
- EC
- 2.3.3.1
- UniProt
- Q8DFP4
- Pockets
- 4 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 56% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Citrate synthase (EC 2.3.3.1) | protein | 426 | 56% helix, 6% strand | Q8DFP4 |
Ligands and binding sites
- FMT · Formic acid · additive · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 735 | 0.72 | 0.78 | 58 | empty |
| 2 | 310 | 0.64 | 0.80 | 46 | empty |
| 3 | 108 | 0.49 | 0.81 | 27 | FMT |
| 4 | 63 | 0.31 | 0.75 | 11 | empty |
Modifications
Observed in the structure: 16 modified (engineered).
Compared structures
- 4E6Y · Type II citrate synthase from Vibrio vulnificus. · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8DFP4
- Elsewhere: RCSB PDB 4E6Y · PDBe 4E6Y · UniProt Q8DFP4
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