Research workbench
Structure of 20MER double-helical RNA composed of CUG/CUG-repeats
Analyse Structure of 20MER double-helical RNA composed of CUG/CUG-repeats in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4E48
- Type
- RNA
- Length
- 60 nucleotides
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5'-R(P*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*U P*GP*C)-3'
- Ligands
- K, SO4
- Pockets
- 1 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D | 5'-R(P*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*U P*GP*C)-3' | rna | 20 | — | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 571 | 0.58 | 0.73 | 31 | empty |
Interfaces
3 interfaces between chains.
- A–B · 967 Ų buried · 101 hydrogen bonds · nucleic-nucleic
- B–D · 92 Ų buried · 2 hydrogen bonds · nucleic-nucleic
- A–D · 84 Ų buried · 3 hydrogen bonds · nucleic-nucleic
Compared structures
- 4E48 · Structure of 20mer double-helical RNA composed of CUG/CUG-repeats · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4E48 · PDBe 4E48
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