X-ray structure of the H225N mutant of TCAB9, a C-3'- methyltransferase, in complex with S-adenosyl-L-homocysteine and sugar product

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 24% strand (DSSP).

Ligands and binding sites

• SAH · S-adenosyl-L-homocysteine · ligand · chains A
• JHZ · (2R,4S,6R)-4-amino-4,6-dimethyl-5-oxotetrahydro-2H-pyran-2-yl [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name) · ligand · chains A
• ZN · Zinc ion · metal · chains A
• EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 4E2Z · X-ray Structure of the H225N mutant of TcaB9, a C-3'-Methyltransferase, in Complex with… · the same entry in another collection · chain A against A, TM-score 1.00

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• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt B5L6K6
• Elsewhere: RCSB PDB 4E2Z · PDBe 4E2Z · UniProt B5L6K6