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Crystal structure of WSN/A influenza nucleoprotein with three mutations (E53D, Y289H, Y313V)
Analyse Crystal structure of WSN/A influenza nucleoprotein with three mutations (E53D… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4DYT
- Type
- protein
- Length
- 1,294 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleocapsid protein
- UniProt
- B4URF1
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 3 distinct chains · 43% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleocapsid protein | protein | 432 | 44% helix, 9% strand | B4URF1 |
| B | Nucleocapsid protein | protein | 429 | 44% helix, 7% strand | B4URF1 |
| C | Nucleocapsid protein | protein | 433 | 42% helix, 5% strand | B4URF1 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 858 | 0.80 | 0.82 | 104 | empty |
| 2 | 795 | 0.79 | 0.82 | 108 | empty |
| 3 | 274 | 0.71 | 0.85 | 46 | empty |
| 4 | 239 | 0.70 | 0.85 | 47 | empty |
| 5 | 53 | 0.68 | 0.97 | 20 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2099 Ų buried · 37 hydrogen bonds · protein-protein
- B–C · 1886 Ų buried · 29 hydrogen bonds · protein-protein
- A–C · 1621 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 4DYT · Crystal Structure of WSN/A Influenza Nucleoprotein with Three Mutations (E53D, Y289H… · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B4URF1
- Elsewhere: RCSB PDB 4DYT · PDBe 4DYT · UniProt B4URF1
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