Research workbench
The crystal structure of tellurite resistance protein from escherichia COLI O157:H7 str. sakai
Analyse The crystal structure of tellurite resistance protein from escherichia COLI… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4DQ0
- Type
- protein
- Length
- 784 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tellurite resistance protein
- UniProt
- Q8X9V6
- Pockets
- 9 · best druggability 0.86
Structure
x-ray diffraction · 3 distinct chains · 28% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tellurite resistance protein | protein | 195 | 29% helix, 30% strand | Q8X9V6 |
| B, C | Tellurite resistance protein | protein | 198 | 27% helix, 30% strand | Q8X9V6 |
| D | Tellurite resistance protein | protein | 193 | 28% helix, 33% strand | Q8X9V6 |
Ligands and binding sites
- NHE · 2-[N-cyclohexylamino]ethane sulfonic acid · additive · 5 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 505 | 0.86 | 0.92 | 73 | NHE |
| 2 | 595 | 0.85 | 0.90 | 71 | empty |
| 3 | 592 | 0.85 | 0.90 | 79 | NHE |
| 4 | 411 | 0.60 | 0.76 | 46 | empty |
| 5 | 201 | 0.58 | 0.80 | 32 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1457 Ų buried · 24 hydrogen bonds · protein-protein
- C–D · 1400 Ų buried · 19 hydrogen bonds · protein-protein
- B–C · 277 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 213 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 211 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 4DQ0 · The crystal structure of tellurite resistance protein from Escherichia coli O157:H7 str.… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8X9V6
- Elsewhere: RCSB PDB 4DQ0 · PDBe 4DQ0 · UniProt Q8X9V6
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