Research workbench
Structure of mouse ORC1 bah domain bound to H4K20ME2
Analyse Structure of mouse ORC1 bah domain bound to H4K20ME2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4DOW
- Type
- protein
- Length
- 331 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Origin recognition complex subunit 1; Histone H4
- UniProt
- Q9Z1N2, P62806
- Pockets
- 3 · best druggability 0.61
Structure
x-ray diffraction · 4 distinct chains · 8% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Origin recognition complex subunit 1 | protein | 157 | 8% helix, 43% strand | Q9Z1N2 |
| B | Origin recognition complex subunit 1 | protein | 152 | 9% helix, 45% strand | Q9Z1N2 |
| C | Histone H4 | protein | 12 | 0% helix, 0% strand | P62806 |
| D | Histone H4 | protein | 10 | 0% helix, 10% strand | P62806 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 508 | 0.61 | 0.75 | 45 | empty |
| 2 | 93 | 0.38 | 0.76 | 21 | empty |
| 3 | 104 | 0.38 | 0.75 | 22 | empty |
Interfaces
4 interfaces between chains.
- A–C · 732 Ų buried · 9 hydrogen bonds · protein-protein
- B–D · 675 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 467 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 166 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (methylation).
Compared structures
- 4DOW · Structure of mouse ORC1 BAH domain bound to H4K20me2 · the same entry in another collection · chain D against D, TM-score 1.00
- Q9Z1N2 · AlphaFold monomer V2.0 prediction for origin recognition complex subunit 1 (Q9Z1N2) · a predicted model of the same protein · chain B against A, TM-score 0.94
- P62806 · AlphaFold monomer V2.0 prediction for histone H4 (P62806) · a predicted model of the same protein · chain D against A, TM-score 0.38
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Z1N2
- Every structure of UniProt P62806
- Elsewhere: RCSB PDB 4DOW · PDBe 4DOW · UniProt Q9Z1N2 · UniProt P62806
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