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Ornithine transcarbamylase from escherichia COLI

Analyse Ornithine transcarbamylase from escherichia COLI in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1AKM
Type: protein
Length: 966 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ornithine transcarbamylase
EC: 2.1.3.3
UniProt: P04391
Pockets: 3 · best druggability 0.88

Structure

x-ray diffraction · 1 distinct chain · 47% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Ornithine transcarbamylase (EC 2.1.3.3)	protein	322	47% helix, 15% strand	P04391

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1122	0.88	0.89	159	empty
2	55	0.31	0.77	14	empty
3	78	0.31	0.74	19	empty

Interfaces

3 interfaces between chains.

A–B · 1113 Å² buried · 20 hydrogen bonds · protein-protein
B–C · 1089 Å² buried · 18 hydrogen bonds · protein-protein
A–C · 1078 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

1AKM · Ornithine transcarbamylase from escherichia COLI · the same entry in another collection · chain A against A, TM-score 1.00
P04391 · AlphaFold monomer V2.0 prediction for ornithine carbamoyltransferase subunit I (P04391) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P04391
Elsewhere: RCSB PDB 1AKM · PDBe 1AKM · UniProt P04391

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