Research workbench
Unwinding the differences of the mammalian period clock proteins from crystal structure to cellular function
Analyse Unwinding the differences of the mammalian period clock proteins from crystal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4DJ3
- Type
- protein
- Length
- 563 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Period circadian protein homolog 3
- UniProt
- O70361
- Pockets
- 10 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 21% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Period circadian protein homolog 3 | protein | 298 | 22% helix, 27% strand | O70361 |
| B | Period circadian protein homolog 3 | protein | 265 | 20% helix, 26% strand | O70361 |
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 986 | 0.68 | 0.73 | 88 | empty |
| 2 | 182 | 0.59 | 0.81 | 28 | empty |
| 3 | 230 | 0.57 | 0.79 | 26 | empty |
| 4 | 120 | 0.46 | 0.78 | 19 | empty |
| 5 | 157 | 0.39 | 0.73 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 809 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 4DJ3 · Unwinding the Differences of the Mammalian PERIOD Clock Proteins from Crystal Structure… · the same entry in another collection · chain A against A, TM-score 1.00
- O70361 · AlphaFold monomer V2.0 prediction for period circadian protein homolog 3 (O70361) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O70361
- Elsewhere: RCSB PDB 4DJ3 · PDBe 4DJ3 · UniProt O70361
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