Research workbench
Core UVRA/TRCF complex
Analyse Core UVRA/TRCF complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4DFC
- Type
- protein
- Length
- 407 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription-repair-coupling factor; Uvrabc system protein a
- EC
- 3.6.4.-, 3.6.1.3
- UniProt
- P30958, P0A698
- Pockets
- 4 · best druggability 0.75
Structure
x-ray diffraction · 4 distinct chains · 19% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription-repair-coupling factor (EC 3.6.4.-) | protein | 85 | 12% helix, 44% strand | P30958 |
| B | Uvrabc system protein a (EC 3.6.1.3) | protein | 121 | 24% helix, 34% strand | P0A698 |
| C | Transcription-repair-coupling factor (EC 3.6.4.-) | protein | 79 | 11% helix, 34% strand | P30958 |
| D | Uvrabc system protein a (EC 3.6.1.3) | protein | 122 | 25% helix, 35% strand | P0A698 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 931 | 0.75 | 0.79 | 72 | empty |
| 2 | 110 | 0.51 | 0.82 | 23 | empty |
| 3 | 98 | 0.44 | 0.79 | 17 | empty |
| 4 | 78 | 0.37 | 0.76 | 14 | empty |
Interfaces
4 interfaces between chains.
- A–B · 931 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 911 Ų buried · 14 hydrogen bonds · protein-protein
- A–D · 484 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 303 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 4DFC · Core UvrA/TRCF complex · the same entry in another collection · chain D against D, TM-score 1.00
- P0A698 · AlphaFold monomer V2.0 prediction for uvrabc system protein a (P0A698) · a predicted model of the same protein · chain B against A, TM-score 0.98
- P30958 · AlphaFold monomer V2.0 prediction for transcription-repair-coupling factor (P30958) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30958
- Every structure of UniProt P0A698
- Elsewhere: RCSB PDB 4DFC · PDBe 4DFC · UniProt P30958 · UniProt P0A698
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.