Research workbench
Crystal structure of the voltage dependent calcium channel beta-2 subunit in complex with the CAV1.2 I-II linker.
Analyse Crystal structure of the voltage dependent calcium channel beta-2 subunit in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4DEY
- Type
- protein
- Length
- 310 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Voltage-dependent L-type calcium channel subunit alpha-1C; Voltage-dependent L-type…
- UniProt
- P15381, P54288
- Ligands
- BR
- Pockets
- 3 · best druggability 0.38
Structure
x-ray diffraction · 2 distinct chains · 47% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Voltage-dependent L-type calcium channel subunit alpha-1C | protein | 29 | 86% helix, 0% strand | P15381 |
| A | Voltage-dependent L-type calcium channel subunit beta-2 | protein | 281 | 43% helix, 19% strand | P54288 |
Ligands and binding sites
- BR · Bromide ion · ion · 17 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 109 | 0.38 | 0.75 | 17 | BR |
| 2 | 68 | 0.36 | 0.77 | 17 | BR |
| 3 | 66 | 0.35 | 0.77 | 19 | BR |
Interfaces
1 interface between chains.
- B–A · 914 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 4DEY · Crystal structure of the Voltage Dependent Calcium Channel beta-2 Subunit in Complex With… · the same entry in another collection · chain B against B, TM-score 1.00
- P54288 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain A against A, TM-score 0.98
- P15381 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain B against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15381
- Every structure of UniProt P54288
- Elsewhere: RCSB PDB 4DEY · PDBe 4DEY · UniProt P15381 · UniProt P54288
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.