Research workbench
Crystal structure of the voltage dependent calcium channel beta-2 subunit in complex with the CAV2.2 I-II linker.
Analyse Crystal structure of the voltage dependent calcium channel beta-2 subunit in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4DEX
- Type
- protein
- Length
- 334 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Voltage-dependent L-type calcium channel subunit beta-2; Voltage-dependent N-type calcium…
- UniProt
- P54288, Q02294
- Pockets
- 4 · best druggability 0.39
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Voltage-dependent L-type calcium channel subunit beta-2 | protein | 289 | 44% helix, 18% strand | P54288 |
| B | Voltage-dependent N-type calcium channel subunit alpha-1B | protein | 45 | 89% helix, 0% strand | Q02294 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 106 | 0.39 | 0.76 | 17 | empty |
| 2 | 69 | 0.37 | 0.78 | 17 | empty |
| 3 | 92 | 0.34 | 0.74 | 17 | empty |
| 4 | 52 | 0.27 | 0.74 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 1005 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 4DEX · Crystal structure of the Voltage Dependent Calcium Channel beta-2 Subunit in Complex With… · the same entry in another collection · chain A against A, TM-score 1.00
- P54288 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain A against A, TM-score 0.96
- Q02294 · AlphaFold monomer V2.0 prediction for voltage-dependent N-type calcium channel subunit… · a predicted model of the same protein · chain B against A, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54288
- Every structure of UniProt Q02294
- Elsewhere: RCSB PDB 4DEX · PDBe 4DEX · UniProt P54288 · UniProt Q02294
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