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Crystal structure of glutathione transferase-like protein IL0419 (target efi-501089) from idiomarina loihiensis L2TR

Analyse Crystal structure of glutathione transferase-like protein IL0419 (target… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4DEJ
Type: protein
Length: 2,409 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutathione S-transferase related protein
UniProt: Q5R0K1
Pockets: 20 · best druggability 0.72

Structure

x-ray diffraction · 7 distinct chains · 53% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutathione S-transferase related protein	protein	202	55% helix, 9% strand	Q5R0K1
B, C, G, H, K	Glutathione S-transferase related protein	protein	201	51% helix, 9% strand	Q5R0K1
D	Glutathione S-transferase related protein	protein	203	53% helix, 10% strand	Q5R0K1
E, I	Glutathione S-transferase related protein	protein	200	53% helix, 11% strand	Q5R0K1
F	Glutathione S-transferase related protein	protein	197	52% helix, 10% strand	Q5R0K1
J	Glutathione S-transferase related protein	protein	202	53% helix, 10% strand	Q5R0K1
L	Glutathione S-transferase related protein	protein	200	54% helix, 11% strand	Q5R0K1

Pockets

20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	649	0.72	0.79	61	empty
2	658	0.72	0.79	66	empty
3	597	0.72	0.80	66	empty
4	604	0.72	0.80	68	empty
5	601	0.70	0.79	66	empty

Interfaces

28 interfaces between chains.

I–J · 1257 Å² buried · 22 hydrogen bonds · protein-protein
K–L · 1242 Å² buried · 19 hydrogen bonds · protein-protein
G–H · 1226 Å² buried · 19 hydrogen bonds · protein-protein
C–D · 1223 Å² buried · 20 hydrogen bonds · protein-protein
E–F · 1212 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

4DEJ · Crystal structure of glutathione transferase-like protein IL0419 (Target EFI-501089) from… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5R0K1
Elsewhere: RCSB PDB 4DEJ · PDBe 4DEJ · UniProt Q5R0K1

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