Research workbench
Structure of PKC in complex with a substrate peptide from par-3
Analyse Structure of PKC in complex with a substrate peptide from par-3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4DC2
- Type
- protein
- Length
- 345 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein kinase C iota type; Partitioning defective 3 homolog
- EC
- 2.7.11.13
- UniProt
- Q62074, Q9Z340
- Ligands
- ADE
- Pockets
- 2 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein kinase C iota type (EC 2.7.11.13) | protein | 329 | 36% helix, 16% strand | Q62074 |
| Z | Partitioning defective 3 homolog | protein | 16 | 0% helix, 6% strand | Q9Z340 |
Ligands and binding sites
- ADE · Adenine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 187 | 0.76 | 0.92 | 33 | ADE |
| 2 | 130 | 0.41 | 0.75 | 28 | empty |
Interfaces
1 interface between chains.
- A–Z · 993 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 4DC2 · Structure of PKC in Complex with a Substrate Peptide from Par-3 · the same entry in another collection · chain A against A, TM-score 1.00
- Q62074 · AlphaFold monomer V2.0 prediction for protein kinase C iota type (Q62074) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q9Z340 · AlphaFold monomer V2.0 prediction for partitioning defective 3 homolog (Q9Z340) · a predicted model of the same protein · chain Z against A, TM-score 0.25
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q62074
- Every structure of UniProt Q9Z340
- Elsewhere: RCSB PDB 4DC2 · PDBe 4DC2 · UniProt Q62074 · UniProt Q9Z340
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