Research workbench

Structure of DNTTIP1 dimerisation domain.

Analyse Structure of DNTTIP1 dimerisation domain. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4D6K
Type: protein
Length: 416 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Deoxynucleotidyltransferase terminal-interacting protein 1
UniProt: Q9H147
Pockets: 4 · best druggability 0.44

Structure

x-ray diffraction · 6 distinct chains · 83% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Deoxynucleotidyltransferase terminal-interacting protein 1	protein	76	75% helix, 0% strand	Q9H147
B	Deoxynucleotidyltransferase terminal-interacting protein 1	protein	69	87% helix, 0% strand	Q9H147
C	Deoxynucleotidyltransferase terminal-interacting protein 1	protein	67	85% helix, 0% strand	Q9H147
D	Deoxynucleotidyltransferase terminal-interacting protein 1	protein	72	81% helix, 0% strand	Q9H147
E	Deoxynucleotidyltransferase terminal-interacting protein 1	protein	67	88% helix, 0% strand	Q9H147
F	Deoxynucleotidyltransferase terminal-interacting protein 1	protein	65	83% helix, 0% strand	Q9H147

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	115	0.44	0.77	17	empty
2	114	0.38	0.74	23	empty
3	126	0.36	0.72	20	empty
4	67	0.29	0.73	16	empty

Interfaces

10 interfaces between chains.

A–B · 2376 Å² buried · 17 hydrogen bonds · protein-protein
E–F · 2126 Å² buried · 16 hydrogen bonds · protein-protein
C–D · 2111 Å² buried · 15 hydrogen bonds · protein-protein
A–C · 317 Å² buried · 1 hydrogen bond · protein-protein
D–F · 298 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

4D6K · Structure of DNTTIP1 dimerisation domain. · the same entry in another collection · chain F against F, TM-score 1.00
Q9H147 · AlphaFold monomer V2.0 prediction for deoxynucleotidyltransferase terminal-interacting… · a predicted model of the same protein · chain C against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H147
Elsewhere: RCSB PDB 4D6K · PDBe 4D6K · UniProt Q9H147

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.