Research workbench
Crystal structure of the class a extended-spectrum beta- lactamase per-2
Analyse Crystal structure of the class a extended-spectrum beta- lactamase per-2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4D2O
- Type
- protein
- Length
- 555 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Per-2 beta-lactamase
- EC
- 3.5.2.6
- UniProt
- A2RP81
- Pockets
- 3 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Per-2 beta-lactamase (EC 3.5.2.6) | protein | 277 | 45% helix, 21% strand | A2RP81 |
| B | Per-2 beta-lactamase (EC 3.5.2.6) | protein | 278 | 46% helix, 20% strand | A2RP81 |
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 887 | 0.75 | 0.79 | 88 | empty |
| 2 | 279 | 0.66 | 0.82 | 36 | empty |
| 3 | 233 | 0.62 | 0.81 | 33 | empty |
Interfaces
1 interface between chains.
- A–B · 1095 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 4D2O · Crystal structure of the class A extended-spectrum beta-lactamase PER- 2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A2RP81
- Elsewhere: RCSB PDB 4D2O · PDBe 4D2O · UniProt A2RP81
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