Research workbench

Crystal structure of the NSL1-wds-NSL2 complex.

Analyse Crystal structure of the NSL1-wds-NSL2 complex. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4CY5
Type: protein
Length: 320 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein will die slowly; Dim gamma-tubulin 1; CG4699, isoform D
EC: 3.6.1.1, 6.1.1.-
UniProt: Q9V3J8, Q9VAF4, A4V2Z1
Pockets: 2 · best druggability 0.74

Structure

x-ray diffraction · 3 distinct chains · 1% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein will die slowly	protein	303	0% helix, 51% strand	Q9V3J8
C	Dim gamma-tubulin 1 (EC 3.6.1.1)	protein	8	0% helix, 0% strand	Q9VAF4
D	CG4699, isoform D (EC 6.1.1.-)	protein	9	33% helix, 0% strand	A4V2Z1

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	515	0.74	0.82	44	empty
2	69	0.55	0.87	18	empty

Interfaces

2 interfaces between chains.

A–D · 630 Å² buried · 9 hydrogen bonds · protein-protein
A–C · 460 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

4CY5 · Crystal structure of the NSL1-WDS-NSL2 complex. · the same entry in another collection · chain A against A, TM-score 1.00
Q9V3J8 · AlphaFold monomer V2.0 prediction for protein will die slowly (Q9V3J8) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9V3J8
Every structure of UniProt Q9VAF4
Every structure of UniProt A4V2Z1
Elsewhere: RCSB PDB 4CY5 · PDBe 4CY5 · UniProt Q9V3J8 · UniProt Q9VAF4 · UniProt A4V2Z1

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