Research workbench
Structural studies of rolling circle replication initiation protein from staphylococcus aureus
Analyse Structural studies of rolling circle replication initiation protein from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4CWE
- Type
- protein
- Length
- 540 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Replication initiation protein, replication initiation protein
- EC
- 5.99.1.2
- UniProt
- P03065, P19529
- Pockets
- 10 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Replication initiation protein, replication initiation protein (EC 5.99.1.2) | protein | 270 | 41% helix, 30% strand | P03065, P19529 |
Pockets
10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 67 | 0.70 | 0.96 | 17 | empty |
| 2 | 378 | 0.61 | 0.77 | 42 | empty |
| 3 | 128 | 0.40 | 0.75 | 22 | empty |
| 4 | 124 | 0.40 | 0.74 | 21 | empty |
| 5 | 84 | 0.37 | 0.76 | 17 | empty |
Interfaces
1 interface between chains.
- A–C · 1428 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 4CWE · Structural studies of rolling circle replication initiation protein from Staphylococcus… · the same entry in another collection · chain A against A, TM-score 1.00
- P03065 · AlphaFold monomer V2.0 prediction for replication initiation protein (P03065) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P19529 · AlphaFold monomer V2.0 prediction for replication initiation protein (P19529) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03065
- Every structure of UniProt P19529
- Elsewhere: RCSB PDB 4CWE · PDBe 4CWE · UniProt P03065 · UniProt P19529
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