Research workbench
Escherichia COLI envz histidine kinase catalytic part fused to archaeoglobus fulgidus AF1503 hamp domain
Analyse Escherichia COLI envz histidine kinase catalytic part fused to archaeoglobus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4CTI
- Type
- protein
- Length
- 855 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Osmolarity sensor protein envz, AF1503
- EC
- 2.7.13.3
- UniProt
- O28769, P0AEJ4
- Pockets
- 8 · best druggability 0.80
Structure
x-ray diffraction · 4 distinct chains · 59% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Osmolarity sensor protein envz, AF1503 (EC 2.7.13.3) | protein | 207 | 60% helix, 11% strand | O28769, P0AEJ4 |
| B | Osmolarity sensor protein envz, AF1503 (EC 2.7.13.3) | protein | 222 | 57% helix, 15% strand | O28769, P0AEJ4 |
| C | Osmolarity sensor protein envz, AF1503 (EC 2.7.13.3) | protein | 203 | 62% helix, 11% strand | O28769, P0AEJ4 |
| D | Osmolarity sensor protein envz, AF1503 (EC 2.7.13.3) | protein | 223 | 57% helix, 13% strand | O28769, P0AEJ4 |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 803 | 0.80 | 0.83 | 64 | empty |
| 2 | 503 | 0.75 | 0.83 | 51 | empty |
| 3 | 499 | 0.73 | 0.81 | 63 | empty |
| 4 | 87 | 0.44 | 0.80 | 16 | empty |
| 5 | 111 | 0.39 | 0.75 | 24 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2731 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 2666 Ų buried · 17 hydrogen bonds · protein-protein
- B–D · 456 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 4CTI · Escherichia coli EnvZ histidine kinase catalytic part fused to Archaeoglobus fulgidus… · the same entry in another collection · chain D against D, TM-score 1.00
- P0AEJ4 · AlphaFold monomer V2.0 prediction for sensor histidine kinase envz (P0AEJ4) · a predicted model of the same protein · chain C against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O28769
- Every structure of UniProt P0AEJ4
- Elsewhere: RCSB PDB 4CTI · PDBe 4CTI · UniProt O28769 · UniProt P0AEJ4
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