Research workbench
Asymmetric DNA-bending in the cre-loxp site-specific recombination synapse
Analyse Asymmetric DNA-bending in the cre-loxp site-specific recombination synapse in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4CRX
- Type
- protein + DNA
- Length
- 714 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (35 nucleotide cre recognition site); Protein (cre recombinase)
- UniProt
- P06956
- Pockets
- 11 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 59% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C, D | DNA (35 nucleotide cre recognition site) | dna | 35 | — | — |
| A, B | Protein (cre recombinase) | protein | 322 | 59% helix, 5% strand | P06956 |
Pockets
11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 794 | 0.80 | 0.84 | 84 | empty |
| 2 | 897 | 0.79 | 0.82 | 97 | empty |
| 3 | 311 | 0.62 | 0.80 | 29 | empty |
| 4 | 308 | 0.55 | 0.76 | 29 | empty |
| 5 | 129 | 0.55 | 0.83 | 25 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1680 Ų buried · 23 hydrogen bonds · protein-protein
- C–B · 1568 Ų buried · 32 hydrogen bonds · protein-nucleic
- C–D · 1536 Ų buried · 115 hydrogen bonds · nucleic-nucleic
- D–A · 1404 Ų buried · 30 hydrogen bonds · protein-nucleic
- D–B · 1382 Ų buried · 29 hydrogen bonds · protein-nucleic
Compared structures
- 4CRX · Asymmetric DNA-bending in the cre-loxp site-specific recombination synapse · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06956
- Elsewhere: RCSB PDB 4CRX · PDBe 4CRX · UniProt P06956
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.