Research workbench
The structure of BCL6 btb (poz) domain in complex with the ansamycin antibiotic rifabutin.
Analyse The structure of BCL6 btb (poz) domain in complex with the ansamycin antibiotic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4CP3
- Type
- protein
- Length
- 244 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- B-cell lymphoma 6 protein
- UniProt
- P41182
- Ligands
- RBT
- Pockets
- 2 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 53% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | B-cell lymphoma 6 protein | protein | 122 | 54% helix, 15% strand | P41182 |
| B | B-cell lymphoma 6 protein | protein | 122 | 52% helix, 15% strand | P41182 |
Ligands and binding sites
- RBT · Rifabutin · ligand · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 150 | 0.46 | 0.76 | 24 | empty |
| 2 | 146 | 0.45 | 0.76 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 1755 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 4CP3 · The structure of BCL6 BTB (POZ) domain in complex with the ansamycin antibiotic rifabutin. · the same entry in another collection · chain A against A, TM-score 1.00
- P41182 · AlphaFold monomer V2.0 prediction for B-cell lymphoma 6 protein (P41182) · a predicted model of the same protein · chain B against A, TM-score 0.34
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P41182
- Elsewhere: RCSB PDB 4CP3 · PDBe 4CP3 · UniProt P41182
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