Research workbench

Crystal structure of human gate-16

Analyse Crystal structure of human gate-16 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4CO7
Type: protein
Length: 236 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gamma-aminobutyric acid receptor-associated protein-like 2
UniProt: P60520
Pockets: 2 · best druggability 0.55

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Gamma-aminobutyric acid receptor-associated protein-like 2	protein	118	32% helix, 22% strand	P60520

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	340	0.55	0.75	38	empty
2	62	0.34	0.76	14	empty

Interfaces

1 interface between chains.

A–B · 49 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

4CO7 · Crystal structure of human GATE-16 · the same entry in another collection · chain A against A, TM-score 1.00
P60520 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor-associated… · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P60520
Elsewhere: RCSB PDB 4CO7 · PDBe 4CO7 · UniProt P60520

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.