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Crystal structure of human FGF18

Analyse Crystal structure of human FGF18 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4CJM
Type: protein
Length: 514 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fibroblast growth factor 18
UniProt: O76093
Ligands: SO4
Pockets: 2 · best druggability 0.46

Structure

x-ray diffraction · 3 distinct chains · 9% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fibroblast growth factor 18	protein	129	9% helix, 41% strand	O76093
B, C	Fibroblast growth factor 18	protein	128	9% helix, 41% strand	O76093
D	Fibroblast growth factor 18	protein	129	9% helix, 43% strand	O76093

Ligands and binding sites

SO4 · Sulfate ion · ion · 13 copies · chains A, D, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	192	0.46	0.75	25	empty
2	61	0.33	0.77	13	empty

Interfaces

3 interfaces between chains.

A–B · 492 Å² buried · 8 hydrogen bonds · protein-protein
A–D · 476 Å² buried · 6 hydrogen bonds · protein-protein
B–C · 321 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

4CJM · Crystal structure of human FGF18 · the same entry in another collection · chain D against D, TM-score 1.00
O76093 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 18 (O76093) · a predicted model of the same protein · chain D against A, TM-score 0.98

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O76093
Elsewhere: RCSB PDB 4CJM · PDBe 4CJM · UniProt O76093

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