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Structure of human MUNC18-2

Analyse Structure of human MUNC18-2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4CCA
Type: protein
Length: 542 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Syntaxin-binding protein 2
UniProt: Q15833
Ligands: CL
Pockets: 5 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Syntaxin-binding protein 2	protein	542	48% helix, 13% strand	Q15833

Ligands and binding sites

CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	364	0.61	0.78	35	empty
2	291	0.56	0.77	35	empty
3	252	0.55	0.77	39	empty
4	63	0.36	0.78	15	empty
5	58	0.34	0.77	12	empty

Compared structures

4CCA · Structure of human Munc18-2 · the same entry in another collection · chain A against A, TM-score 1.00
Q15833 · AlphaFold monomer V2.0 prediction for syntaxin-binding protein 2 (Q15833) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15833
Elsewhere: RCSB PDB 4CCA · PDBe 4CCA · UniProt Q15833

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