Research workbench
Pestivirus NS3 helicase
Analyse Pestivirus NS3 helicase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4CBH
- Type
- protein
- Length
- 1,376 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Serine protease NS3
- EC
- 3.4.21.113, 3.6.1.15, 3.6.4.13
- UniProt
- P19712
- Pockets
- 19 · best druggability 0.72
Structure
x-ray diffraction · 4 distinct chains · 41% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Serine protease NS3 (EC 3.4.21.113, 3.6.1.15, 3.6.4.13) | protein | 333 | 42% helix, 19% strand | P19712 |
| B | Serine protease NS3 (EC 3.4.21.113, 3.6.1.15, 3.6.4.13) | protein | 330 | 43% helix, 19% strand | P19712 |
| C | Serine protease NS3 (EC 3.4.21.113, 3.6.1.15, 3.6.4.13) | protein | 329 | 40% helix, 19% strand | P19712 |
| D | Serine protease NS3 (EC 3.4.21.113, 3.6.1.15, 3.6.4.13) | protein | 384 | 40% helix, 20% strand | P19712 |
Pockets
19 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 637 | 0.72 | 0.79 | 64 | empty |
| 2 | 235 | 0.66 | 0.84 | 28 | empty |
| 3 | 206 | 0.65 | 0.84 | 26 | empty |
| 4 | 151 | 0.62 | 0.85 | 25 | empty |
| 5 | 163 | 0.62 | 0.84 | 26 | empty |
Interfaces
4 interfaces between chains.
- B–C · 1272 Ų buried · 40 hydrogen bonds · protein-protein
- A–D · 1269 Ų buried · 41 hydrogen bonds · protein-protein
- A–B · 77 Ų buried · 2 hydrogen bonds · protein-protein
- C–D · 49 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4CBH · Pestivirus NS3 helicase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19712
- Elsewhere: RCSB PDB 4CBH · PDBe 4CBH · UniProt P19712
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.