Research workbench
Structure of influenza a H5N1 PB2 cap-binding domain with bound cap analogue (compound 8F)
Analyse Structure of influenza a H5N1 PB2 cap-binding domain with bound cap analogue… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4CB5
- Type
- protein
- Length
- 162 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polymerase basic subunit 2
- UniProt
- Q2LG68
- Ligands
- 93G, CL
- Pockets
- 1 · best druggability 0.42
Structure
x-ray diffraction · 1 distinct chain · 25% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polymerase basic subunit 2 | protein | 162 | 25% helix, 41% strand | Q2LG68 |
Ligands and binding sites
- 93G · 9-N-(3-carboxy-4-hydroxyphenyl)ketomethyl-7-N-methylguanine · ligand · chains A
- CL · Chloride ion · ion · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 99 | 0.42 | 0.78 | 20 | 93G, CL |
Compared structures
- 4CB5 · Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8f) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2LG68
- Elsewhere: RCSB PDB 4CB5 · PDBe 4CB5 · UniProt Q2LG68
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