Research workbench
Three-dimensional structure of dengue virus serotype 1 complexed with 2 hmab 14C10 Fab
Analyse Three-dimensional structure of dengue virus serotype 1 complexed with 2 hmab… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4CAU
- Type
- protein
- Length
- 1,588 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Envelope protein E; Fab 14C10
- UniProt
- Q689G3
- Pockets
- 6 · best druggability 0.48
Structure
electron microscopy · 2 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Envelope protein E | protein | 376 | 0% helix, 0% strand | Q689G3 |
| D, E | Fab 14C10 | protein | 230 | 0% helix, 0% strand | — |
Pockets
6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 195 | 0.48 | 0.73 | 52 | empty |
| 2 | 186 | 0.47 | 0.73 | 45 | empty |
| 3 | 122 | 0.40 | 0.73 | 35 | empty |
| 4 | 107 | 0.38 | 0.73 | 24 | empty |
| 5 | 73 | 0.31 | 0.72 | 22 | empty |
Interfaces
5 interfaces between chains.
- B–C · 156 Ų buried · 0 hydrogen bonds · protein-protein
- A–E · 106 Ų buried · 0 hydrogen bonds · protein-protein
- C–D · 93 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 77 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 50 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4CAU · Three-dimensional structure of dengue virus serotype 1 complexed with 2 hmab 14C10 Fab · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q689G3
- Elsewhere: RCSB PDB 4CAU · PDBe 4CAU · UniProt Q689G3
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