Research workbench
Structure of the nucleoplasmin-like N-terminal domain of drosophila FKBP39
Analyse Structure of the nucleoplasmin-like N-terminal domain of drosophila FKBP39 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4CA9
- Type
- protein
- Length
- 490 residues
- Chains
- 5
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 39 kda FK506-binding nuclear protein
- EC
- 5.2.1.8
- UniProt
- P54397
- Pockets
- 1 · best druggability 0.76
Structure
solution nmr · 1 distinct chain · 0% helix, 66% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | 39 kda FK506-binding nuclear protein (EC 5.2.1.8) | protein | 98 | 0% helix, 66% strand | P54397 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 607 | 0.76 | 0.82 | 81 | empty |
Interfaces
5 interfaces between chains.
- B–C · 1025 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 1022 Ų buried · 16 hydrogen bonds · protein-protein
- A–E · 1021 Ų buried · 16 hydrogen bonds · protein-protein
- C–D · 1021 Ų buried · 16 hydrogen bonds · protein-protein
- D–E · 1015 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 4CA9 · Structure of the Nucleoplasmin-like N-terminal domain of Drosophila FKBP39 · the same entry in another collection · chain E against E, TM-score 1.00
- P54397 · AlphaFold monomer V2.0 prediction for 39 kda FK506-binding nuclear protein (P54397) · a predicted model of the same protein · chain D against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54397
- Elsewhere: RCSB PDB 4CA9 · PDBe 4CA9 · UniProt P54397
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