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Structural basis for the microtubule binding of the human kinetochore ska complex

Analyse Structural basis for the microtubule binding of the human kinetochore ska… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4CA0
Type: protein
Length: 238 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Spindle and kinetochore-associated protein 1
UniProt: Q96BD8
Pockets: 3 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 53% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Spindle and kinetochore-associated protein 1	protein	119	53% helix, 11% strand	Q96BD8

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	278	0.59	0.79	36	empty
2	73	0.33	0.75	16	empty
3	59	0.29	0.74	13	empty

Interfaces

1 interface between chains.

A–B · 693 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

4CA0 · Structural Basis for the microtubule binding of the human kinetochore Ska complex · the same entry in another collection · chain A against A, TM-score 1.00
Q96BD8 · AlphaFold monomer V2.0 prediction for spindle and kinetochore- associated protein 1… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96BD8
Elsewhere: RCSB PDB 4CA0 · PDBe 4CA0 · UniProt Q96BD8

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