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Structural basis for the microtubule binding of the human kinetochore ska complex

Analyse Structural basis for the microtubule binding of the human kinetochore ska… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4C9Y
Type: protein
Length: 246 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Spindle and kinetochore-associated protein 1
UniProt: Q96BD8
Pockets: 1 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 54% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Spindle and kinetochore-associated protein 1	protein	123	54% helix, 8% strand	Q96BD8

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	104	0.37	0.74	22	empty

Interfaces

1 interface between chains.

A–B · 270 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

4C9Y · Structural Basis for the microtubule binding of the human kinetochore Ska complex · the same entry in another collection · chain A against A, TM-score 1.00
Q96BD8 · AlphaFold monomer V2.0 prediction for spindle and kinetochore- associated protein 1… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96BD8
Elsewhere: RCSB PDB 4C9Y · PDBe 4C9Y · UniProt Q96BD8

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