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Crystal structure of the minimal pho-sfmbt complex (P6122 spacegroup)

Analyse Crystal structure of the minimal pho-sfmbt complex (P6122 spacegroup) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
4C5G
Type
protein
Length
471 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Polycomb protein sfmbt; Polycomb protein pho
UniProt
Q9VK33, Q8ST83
Pockets
1 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 15% helix, 32% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
APolycomb protein sfmbtprotein44116% helix, 29% strandQ9VK33
BPolycomb protein phoprotein300% helix, 67% strandQ8ST83

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
16920.810.8574empty

Interfaces

1 interface between chains.

  • A–B · 965 Ų buried · 9 hydrogen bonds · protein-protein

Compared structures

  • 4C5G · Crystal structure of the minimal Pho-Sfmbt complex (P6122 spacegroup) · the same entry in another collection · chain A against A, TM-score 1.00
  • Q9VK33 · AlphaFold monomer V2.0 prediction for polycomb protein sfmbt (Q9VK33) · a predicted model of the same protein · chain A against A, TM-score 1.00
  • Q8ST83 · AlphaFold monomer V2.0 prediction for polycomb protein pho (Q8ST83) · a predicted model of the same protein · chain B against A, TM-score 0.65

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