Research workbench

The carbonic anhydrase from thermovibrio ammonificans reveals an interesting intermolecular disulfide contributing to increasing thermal stability of this enzyme

Analyse The carbonic anhydrase from thermovibrio ammonificans reveals an interesting… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4C3T
Type: protein
Length: 450 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Carbonate dehydratase
EC: 4.2.1.1
UniProt: E8T502
Ligands: ZN, CL
Pockets: 2 · best druggability 0.48

Structure

x-ray diffraction · 1 distinct chain · 17% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Carbonate dehydratase (EC 4.2.1.1)	protein	225	17% helix, 33% strand	E8T502

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B
CL · Chloride ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	108	0.48	0.80	22	empty
2	111	0.47	0.79	22	empty

Interfaces

1 interface between chains.

A–B · 65 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

4C3T · The Carbonic anhydrase from Thermovibrio ammonificans reveals an interesting… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E8T502
Elsewhere: RCSB PDB 4C3T · PDBe 4C3T · UniProt E8T502

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.