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Crystal structure of the CTPB(V118Y) mutant

Analyse Crystal structure of the CTPB(V118Y) mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4C2H
Type: protein
Length: 870 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Carboxy-terminal processing protease ctpb
EC: 3.4.21.102
UniProt: O35002
Pockets: 7 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Carboxy-terminal processing protease ctpb (EC 3.4.21.102)	protein	435	34% helix, 23% strand	O35002

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	768	0.74	0.79	59	empty
2	736	0.73	0.79	60	empty
3	732	0.72	0.78	79	empty
4	501	0.67	0.78	75	empty
5	78	0.37	0.77	18	empty

Interfaces

1 interface between chains.

A–B · 2865 Å² buried · 38 hydrogen bonds · protein-protein

Compared structures

4C2H · Crystal structure of the CtpB(V118Y) mutant · the same entry in another collection · chain A against A, TM-score 1.00
O35002 · AlphaFold monomer V2.0 prediction for carboxy-terminal processing protease ctpb (O35002) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O35002
Elsewhere: RCSB PDB 4C2H · PDBe 4C2H · UniProt O35002

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