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The structure of the TSI2 dimer with a disulfide bond

Analyse The structure of the TSI2 dimer with a disulfide bond in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4C18
Type: protein
Length: 151 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TSI2
UniProt: Q9I0D9
Pockets: 1 · best druggability 0.46

Structure

x-ray diffraction · 2 distinct chains · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	TSI2	protein	76	68% helix, 0% strand	Q9I0D9
B	TSI2	protein	75	72% helix, 0% strand	Q9I0D9

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	55	0.46	0.84	15	empty

Interfaces

1 interface between chains.

A–B · 1094 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

4C18 · The structure of the Tsi2 dimer with a disulfide bond · the same entry in another collection · chain A against A, TM-score 1.00
Q9I0D9 · AlphaFold monomer V2.0 prediction for immune protein TSI2 (Q9I0D9) · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9I0D9
Elsewhere: RCSB PDB 4C18 · PDBe 4C18 · UniProt Q9I0D9

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