Research workbench
Crystal structure of human glycogen branching enzyme (GBE1)
Analyse Crystal structure of human glycogen branching enzyme (GBE1) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4BZY
- Type
- protein
- Length
- 1,918 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 1,4-alpha-glucan-branching enzyme
- EC
- 2.4.1.18
- UniProt
- Q04446
- Pockets
- 15 · best druggability 0.73
Structure
x-ray diffraction · 3 distinct chains · 31% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 1,4-alpha-glucan-branching enzyme (EC 2.4.1.18) | protein | 637 | 31% helix, 24% strand | Q04446 |
| B | 1,4-alpha-glucan-branching enzyme (EC 2.4.1.18) | protein | 644 | 31% helix, 24% strand | Q04446 |
| C | 1,4-alpha-glucan-branching enzyme (EC 2.4.1.18) | protein | 637 | 30% helix, 25% strand | Q04446 |
Pockets
15 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 886 | 0.73 | 0.78 | 82 | empty |
| 2 | 972 | 0.73 | 0.77 | 97 | empty |
| 3 | 1150 | 0.73 | 0.76 | 69 | empty |
| 4 | 230 | 0.57 | 0.79 | 35 | empty |
| 5 | 179 | 0.56 | 0.80 | 26 | empty |
Interfaces
2 interfaces between chains.
- B–C · 943 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 768 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 4BZY · Crystal structure of human glycogen branching enzyme (GBE1) · the same entry in another collection · chain A against A, TM-score 1.00
- Q04446 · AlphaFold monomer V2.0 prediction for 1,4-alpha-glucan-branching enzyme (Q04446) · a predicted model of the same protein · chain C against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q04446
- Elsewhere: RCSB PDB 4BZY · PDBe 4BZY · UniProt Q04446
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