Research workbench
Crystal structure of human myosin 1C in complex with calmodulin in the pre-power stroke state
Analyse Crystal structure of human myosin 1C in complex with calmodulin in the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4BYF
- Type
- protein
- Length
- 1,690 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Unconventional myosin-ic; Calmodulin
- EC
- 3.6.4.1
- UniProt
- O00159, P62158
- Ligands
- AOV, MG
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 4 distinct chains · 51% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Unconventional myosin-ic (EC 3.6.4.1) | protein | 698 | 50% helix, 13% strand | O00159 |
| B | Calmodulin | protein | 148 | 58% helix, 8% strand | P62158 |
| C | Unconventional myosin-ic (EC 3.6.4.1) | protein | 696 | 50% helix, 13% strand | O00159 |
| D | Calmodulin | protein | 148 | 59% helix, 8% strand | P62158 |
Ligands and binding sites
- AOV · Adp orthovanadate · ligand · 2 copies · chains A, C
- MG · Magnesium ion · metal · 3 copies · chains A, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 855 | 0.79 | 0.82 | 55 | empty |
| 2 | 767 | 0.78 | 0.82 | 53 | empty |
| 3 | 793 | 0.75 | 0.80 | 85 | MG, AOV |
| 4 | 823 | 0.71 | 0.77 | 68 | empty |
| 5 | 446 | 0.67 | 0.79 | 53 | MG, AOV |
Interfaces
4 interfaces between chains.
- C–D · 1942 Ų buried · 23 hydrogen bonds · protein-protein
- A–B · 1909 Ų buried · 21 hydrogen bonds · protein-protein
- A–D · 351 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 319 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4BYF · Crystal structure of human Myosin 1c in complex with calmodulin in the pre-power stroke… · the same entry in another collection · chain A against A, TM-score 1.00
- O00159 · AlphaFold monomer V2.0 prediction for unconventional myosin-ic (O00159) · a predicted model of the same protein · chain A against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00159
- Every structure of UniProt P62158
- Elsewhere: RCSB PDB 4BYF · PDBe 4BYF · UniProt O00159 · UniProt P62158
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.