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Crystal structure of the human metapneumovirus phosphoprotein tetramerization domain

Analyse Crystal structure of the human metapneumovirus phosphoprotein tetramerization… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4BXT
Type: protein
Length: 199 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphoprotein P
UniProt: Q91KZ5
Pockets: 2 · best druggability 0.45

Structure

x-ray diffraction · 6 distinct chains · 81% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phosphoprotein P	protein	24	83% helix, 0% strand	Q91KZ5
B, E, F	Phosphoprotein P	protein	25	84% helix, 0% strand	Q91KZ5
C	Phosphoprotein P	protein	25	84% helix, 0% strand	Q91KZ5
D	Phosphoprotein P	protein	26	77% helix, 0% strand	Q91KZ5
G	Phosphoprotein P	protein	26	73% helix, 0% strand	Q91KZ5
H	Phosphoprotein P	protein	23	87% helix, 0% strand	Q91KZ5

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	60	0.45	0.84	13	empty
2	131	0.42	0.75	19	empty

Interfaces

16 interfaces between chains.

A–B · 660 Å² buried · 3 hydrogen bonds · protein-protein
E–H · 642 Å² buried · 2 hydrogen bonds · protein-protein
F–G · 632 Å² buried · 2 hydrogen bonds · protein-protein
E–F · 616 Å² buried · 1 hydrogen bond · protein-protein
C–D · 599 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

4BXT · Crystal structure of the human metapneumovirus phosphoprotein tetramerization domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q91KZ5
Elsewhere: RCSB PDB 4BXT · PDBe 4BXT · UniProt Q91KZ5

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